Figure 1: C.elegans Body Diagram. Found at http://en.wikipedia.org/wiki/Caenorhabditis_elegans
caenorhabditis Elegans: A model organism
For the purpose of this study and because of personal preferences which you can read about here, I will be using C.elegans as my model organism. It is a perfect model organism for a study such as this since it has a short life span, high viability, high transparency, high fecundity and is very easily and beautifully imaged as you can see below.
It's 14-3-3sigma homolog, par-5, has been studied extensively and there are many papers describing its function in C.elegans involving translation (meiotic and local), cell division and regulation of various other biological processes. However, little is known about exactly what 14-3-3sigma does in C.elegans and its exact role in cell division. Previous research has shown that 14-3-3sigma has a role in local translation that happens mitotically in the cell and not during the usual time of the cell cycle.
14-3-3sigma has also been shown to interact with other proteins in the cell that function with cell division, mitotic regulation, apoptosis and growth factors. Its role in development is still being researched, which leads me to what I am trying to accomplish in this study
C.elegans matures to an adult in 72 hours and an example of its life cycle is shown below.
To learn more about this organism, head to Worm Base.
It's 14-3-3sigma homolog, par-5, has been studied extensively and there are many papers describing its function in C.elegans involving translation (meiotic and local), cell division and regulation of various other biological processes. However, little is known about exactly what 14-3-3sigma does in C.elegans and its exact role in cell division. Previous research has shown that 14-3-3sigma has a role in local translation that happens mitotically in the cell and not during the usual time of the cell cycle.
14-3-3sigma has also been shown to interact with other proteins in the cell that function with cell division, mitotic regulation, apoptosis and growth factors. Its role in development is still being researched, which leads me to what I am trying to accomplish in this study
C.elegans matures to an adult in 72 hours and an example of its life cycle is shown below.
To learn more about this organism, head to Worm Base.