What is protein homology?Protein homology is the study of organisms that have similar protein structure and amino acid makeup that has been passed down from a common ancestor [1] . In this case, I have looked at thirteen organisms with a variety of epithelial linings to get an idea of how similar the makeup of my various organisms of interest are. It was very likely that organisms that look similar to each other have the most similar homology, but sometimes you uncover a different results than expected. Using BLAST, PubMed and Clustal Omega, all of these similarities could be determined.
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Rhesus Macaque (Macaca mulatta)
14-3-3 protein sigma, 248aa Accessions: NP_001245060, XP_001110282 FASTA |
dISCUSSION
The organisms above range in kingdom and type of animal, many primates have a higher identity than some of the other organisms. This protein is highly conserved in mammals and decreases over the time period. It is interesting to note that this gene localizes in the nucleus of the epithelial cells and plants do not have them. Further research could be done on the specific phenotypes found in each organism.
References:
[1] Homologous genes. (n.d.). Retrieved March 27, 2015, from http://evolution.berkeley.edu/evolibrary/article/1_0_0/eyes_10